Alterations in NF- B function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF- B
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چکیده
منابع مشابه
Alterations in NF-kB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kB
Stratified epithelium contains a mitotically active basal layer of cells that cease proliferating, then migrate outwards and undergo terminal differentiation. The control of this process, which is abnormal in cutaneous neoplasia and inflammation, is not well understood. In normal epidermis, NF-kB proteins were found to exist in the cytoplasm of basal cells and then to localize in the nuclei of ...
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Chemotherapeutic agents simultaneously induce transcription factors p53 and NF B. p53 induction can activate an apoptotic program, and resistance to chemotherapy correlates with the loss of a functional p53 pathway. By contrast, NF B prevents apoptosis in response to chemotherapeutic agents. We have analyzed the p53 response in IKK1/2 / MEFs, which lack detectable NF B activity. Compared to WT ...
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The regulation of gene expression, which allows a living cell to express a defined set of genes according to its environmental conditions and stage of development, occurs primarily at the level of transcription. The precise temporal and spatial control of the transcription factor NFκB has become a paradigm for the complexity of transcriptional regulation in eukaryotes. IκB, the inhibitor and ce...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.5.2307